Matrix models as a tool to improve rational and cost-effective drug selection

Dr. Robert Janknegt, Director of Pharmacy,

OrbisMedicalCenter, Sittard-Geleen, the Netherlands

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Dr.Janknegt is an international specialist on rational drug selection, by means of interactive tools (SOJA and InforMatrix), which can be used to optimise pharmacotherapy and formulary decision making. See websites for further information. Spectacular results during an on-going project (STEPSelect) in Northern Ireland, leading to improved quality of prescribing, combined with a major cost reduction.

Prof. Michael Scott, Director of Pharmacy,

AntrimAreaHospital, Antrim, Northern Ireland

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ABSTRACT:

The drug selection process regarding formulary management is complex and the decisions made by prescribers or policy makers may have consequences for others (patients) who will have to accept the choices that have been made. Therefore it is essential that the selection process is fully transparent and that all key stakeholders are involved in the selection process. This makes it imperative that the selection process is reproducible, with guaranteed quality.

Although everyone would agree that drug selection should be a rational process ("Evidence based medicine”), based on criteria such as clinical efficacy, documented effects on clinically relevant endpoints, safety, tolerability, experience, drug interactions, dosage frequency and cost, many other factors may play a major role in drug selection.